Table 1 List of BioProject datasets of viral infections used in this study, and their characteristics
From: Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections
BioProject Accession | Virus | Time of Infection | Organism | Virus Delivery | Tissue | ADAR1 Expression | ADAR2 Expression | ADAR3 Expression | Editing Site Number | Editing Sites with Increased Editing | Editing Sites with Decreased Editing | Â |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
PRJNA422858 | HCMV# | Infants at time of diagnosis | Human | Natural | Blood | Up (p_adj = 7.31E-07) | Up (p_adj = 7.59E-05 and 4.00E-03) | No Change | – | – | – | – |
PRJEB38849 | MCMV | Newborn mice, analyzed after 8 days infection | Mouse | inoculated i.p. with 400 PFU | Microglia | Up (p_adj < 0.001) | No Change | No Change | Up (p = 0.01129) | 21 | 0 | Up (p = 0.0004) |
PRJNA487357 | ZIKV | E10.5/E14.5 | Mouse | unspecified | Brain | Up (p_adj < 0.001) | No Change | No Change | Up (p = 0.01877) | 12 | 0 | Up (p = 0.004) |
PRJNA358758 | ZIKV | E15.5/P3 | Mouse | 6.5 × 105 PFU injected into one side of the lateral ventricle (LV) | Brain | Up (p_adj < 0.001) | Down (p_adj < 0.001) | Down (p_adj < 0.001) | Up (p = 0.0007137) | 137 | 11 | Up (p = 0.006) |
PRJNA551246 | ZIKV | Analysis after 48 hours infection | Human | Inoculated for 1 hr. with virus at MOI 1 | hiNPC | Higher in PE243V (p_adj < 0.001) and FSS1302 (p_adj < 0.001) than control; higher in FSS1302 than PE243V (p_adj < 0.001) | No Change | No Change | No Change | 3 in FSS1302; 1 in PE243V; 1 in both | 2 in FSS1302; 1 in PE243V; 1 higher in PE243V than FSS1302 | Increased in both ZIKV strains (p < 0.0001), no change between ZIKV strains |