Whole genome-scale assessment of gene fitness of Novosphingobium aromaticavorans during spaceflight

Sharma, Gayatri; Zee, Peter C.; Zea, Luis; Curtis, Patrick D.

doi:10.1186/s12864-023-09799-z

BMC Genomics

Table 2 Summary of 20 common genes identify through Cook’s distance and Welch’s t-test

From: Whole genome-scale assessment of gene fitness of Novosphingobium aromaticavorans during spaceflight

Locus Tag	ED (G)	ED (ISS)	Influential (> 4/n Cook’s distance)	Welch’s t. test (p ≤ 0.05)	low fitness	Gene Product	COG	Gene functions
Saro_0557	0.518163423	0.286886804	Yes	0.00213106	ISS	nuclease (SNase-like)	nuclease (SNase-like)	Hydrolase activity, a on ester bonds
Saro_1063	0.48046069	0.278912913	Yes	0.008205582	ISS	hypothetical protein	hypothetical protein
Saro_1339	0.454544094	0.234475765	Yes	0.029067257	ISS	acyl carrier protein	[I] Lipid transport and metabolism [Q] Secondary metabolites biosynthesis, transport and catabolism	Transports the growing fatty acid chain between enzyme domains of fatty acid synthase (FAS) during biosynthesis
Saro_1351	0.516126475	0.394114113	Yes	0.018421515	ISS	transcriptional regulator, AsnC family	[K] Transcription	Amino acid metabolism, regulation of transport processes or cell morphogenesis.
Saro_1612	0.51261362	0.337969777	Yes	0.009293063	ISS	hypothetical protein	hypothetical protein
Saro_2006	0.513531587	0.278627056	Yes	0.005967643	ISS	hypothetical protein	hypothetical protein
Saro_2014	0.537626755	0.343486828	Yes	0.038028149	ISS	heat shock protein Hsp20	[O] Posttranslational modification, protein turnover, chaperones	Molecular chaperone IbpA, HSP20 family
Saro_2033	0.455425818	0.236599201	Yes	0.029024472	ISS	hypothetical protein	hypothetical protein
Saro_2246	0.504140769	0.293825409	Yes	0.018279786	ISS	hypothetical protein	hypothetical protein
Saro_2725	0.472698515	0.251977191	Yes	0.004722643	ISS	hypothetical protein	hypothetical protein
Saro_2874	0.500877253	0.292535145	Yes	0.009886839	ISS	Twin-arginine translocation pathway signal	Twin-arginine translocation pathway signal	Export of folded proteins across the cytoplasmic membrane of bacteria.
Saro_3006	0.535912608	0.464719652	Yes	0.041766568	ISS	hypothetical protein	hypothetical protein
Saro_3077	0.531596141	0.354834984	Yes	0.031025729	ISS	hypothetical protein	hypothetical protein
Saro_3890	0.520015364	0.428781833	Yes	0.033590134	ISS	fatty acid desaturase	[I] Lipid transport and metabolism	Catalyze the biosynthesis of monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs).
Saro_3949	0.530724879	0.416706415	Yes	0.010790725	ISS	hypothetical protein	hypothetical protein
Saro_3426	0.528715758	0.320315505	Yes	0.0171952	ISS	Glyoxalase/bleomycin resistance protein/dioxygenase	[Q] Secondary metabolites biosynthesis, transport and catabolism	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme
Saro_3444	0.482016209	0.257009743	Yes	0.020568395	ISS	hypothetical protein	hypothetical protein
Saro_3600	0.440391595	0.261442673	Yes	0.00208821	ISS	short-chain dehydrogenase/reductase SDR	[I] Lipid transport and metabolism	NAD(P)(H)-dependent oxidoreductases involved in metabolism of a lipids and lipid A modification
Saro_3746	0.528729413	0.418257138	Yes	0.021791329	ISS	hypothetical protein	hypothetical protein
Saro_3770	0.429515955	0.238187673	Yes	0.002242064	ISS	regulatory protein, LuxR	transcription regulatory protein, LuxR	Coordinates the expression of genes, including encoding for virulence factors and antibiotics biosynthesis

*ED: Effective density, *G: Ground, *ISS: International Space Station

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ISSN: 1471-2164

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