Fig. 4

Integrative analysis of downregulated miRNAs and their upregulated mRNA targets. A miRNA-mRNA target interaction network depicting 5144 interactions (edges) between 128 differentially expressed miRNAs (purple nodes) and 2134 upregulated mRNA targets (red nodes). B A subset of the miRNA-mRNA target interaction network in (A) depicting the most significant negatively correlated pairs (Pearson correlation estimate < -0.7). C Top 10 gene ontology (GO) terms (biological functions) enriched amongst upregulated mRNA targets in fetal hearts between weeks 8 and 19 of gestation. Data was analyzed with DAVID v2023q1 using Benjamini correction. Abbreviations: HADHA/B, Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha/beta; CYC1, Cytochrome c1; UQCRC1, Ubiquinol-cytochrome c reductase core protein 1; ALDOC, Aldose, fructose-bisphosphate C; ATP, Adenosine triphosphate