Fig. 5

Integrative analysis of upregulated miRNAs and their downregulated mRNA targets. A miRNA-mRNA target interaction network depicting top 5% (1750 edges) negatively correlated 60 differentially expressed miRNAs (purple nodes) and downregulated mRNA targets (red nodes). B A subset of the miRNA-mRNA target interaction network in (A) depicting the most significant negatively correlated pairs (Pearson correlation estimate < -0.85). C Top 10 gene ontology (GO) terms (biological functions) enriched amongst downregulated mRNA targets in fetal hearts between weeks 8 and 18 of gestation. Data was analyzed with DAVID v2023q1 using Benjamini correction. Abbreviations: EML4, EMAP like 4; TTF2, Transcription termination factor 2; DNMT3B, DNA methyltransferase 3 beta; AUTS2, Activator of transcription and developmental regulator; TICRR, TOPBP1 interacting checkpoint and replication regulator; MCM3, Minichromosome maintenance complex component 3; AKAP8, A-kinase anchoring protein 8