Fig. 6

miRNA-mRNA-protein regulatory networks in fetal heart development. A Heatmap displaying normalized abundance (Z-scores) of differently abundant proteins identified as miRNA targets between 10- (n = 3) and 18-weeks-old (n = 3) fetal heart samples (P < 0.05). Enriched proteins are in red, and depleted proteins are in blue. B GO (gene ontology) biological processes enrichment among enriched proteins whose expression negatively correlates with miRNAs differential expression. GO enrichment was analyzed using g:profiler. C miRNA-mRNA targets-proteins interaction network depicting 58 interactions (edges) between 32 differentially expressed miRNAs (purple nodes) and 22 enriched proteins (red nodes) between 10- and 19-week-old fetal hearts. D miRNA-mRNA targets-proteins interaction network depicting 85 interactions (edges) between 66 differentially expressed miRNAs (purple nodes) and 4 depleted proteins (red nodes) between 10- and 18-week-old fetal hearts. Abbreviations: SFPQ, Splicing factor proline and glutamine-rich, HNRNPA2B1, Heterogeneous nuclear ribonucleoprotein A2/B1; FBN2, Fibrillin 2; HBZ, Hemoglobin subunit zeta