Fig. 6

Metabolic and structurally related glia-typical support functions in T. marmoratus camera eyes. A Genes associated with the pentose phosphate pathway (PPP), including zwischenferment (zwi), phosphogluconate dehyrogenase (pgd), and glycogen binding subunit 76A (gbs76A), and with glycogenesis, including 1,4-alpha-glucan branching enzyme (abge), glycogenin (gyg) isoforms I and B, and ATP citrate lyase (atpcl). For glucose homeostasis, we found glucose transmembrane transporter pippin and three isoforms of glucose transporter 1 (glut1); isoforms S and P are enriched in the retina region, whereas isoform W is enriched in the SupCs. B A glutamate receptor and an associated protein (eye-enriched kainate receptor (Ekar)) as well as CG11155 are enriched in the retina, whereas kainate-type ionotropic glutamate receptor subunit 1D (Kair1D) and a glutamate receptor activator clumsy are enriched in the SupCs. Glutamine synthetase enzymes gs1 and gs2 are also enriched in the SupCs. C SupCs are enriched in several genes related to fatty acid metabolism including CG31683, CG31522, CG4020, CG6847, CG1441, waterproof (wat), desaturase 2 (desat2), saccherophin dehydrogenase 2 (sccpdh2), and fatty acid transporter protein 2 (fatp2). Structural support mediated by cell adhesion molecules is another important glial function. We found SupC enrichment of the following cell adhesion molecules: innexin 3 (inx3), vinculin (vin), unzipped (uzip), smallish (smash), and fat (ft)