Table 1 Disease coverage comparison. Union of top 20 disease-related pathways for each database by searching associated pathway titles and descriptions or captions. Disease names were compiled from the Comparative Toxicogenomics Database [14]. Average pathway counts among the top 20 disease matches per database are given in parentheses in column headers. The pathway count for the most represented disease per database is in bold italics

Breast cancer

1954

20

6

3

Fibrosis

959

4

8

4

Alzheimer

874

6

12

2

Colorectal cancer

817

10

5

1

Prostate cancer

794

1

7

1

Lung cancer

792

7

7

5

Lymphoma

692

9

2

3

Leukemia

673

23

6

3

Melanoma

659

8

4

1

Insulin resistance

586

1

4

5

Obesity

529

4

8

4

Ischemia

483

2

2

0

Parkinson

464

4

6

2

Pancreatic cancer

435

1

6

1

Tuberous sclerosis

413

1

0

0

Hepatitis

397

4

3

5

Hypertrophy

380

0

6

4

Arthritis

372

6

4

1

Hypertension

358

2

4

2

Glioblastoma

343

8

2

1

Atherosclerosis

300

6

4

3

SARS-CoV-2

265

3

18

1

Retinoblastoma

204

3

5

2

Heart failure

185

0

2

3

Anemia

179

6

1

1

Diabetes mellitus

177

1

3

4

Schizophrenia

146

4

2

0

Renal cell carcinoma

142

0

5

1

Cardiomyopathy

133

1

1

5

Huntington

121

1

3

2

Multiple myeloma

120

4

0

0

Hyperplasia

100

2

2

3

AML^a

96

6

1

1

Ulcer

67

1

0

3

Hyperlipidemia

33

0

6

0

Hemophilia A

3

4

0

0

CDG^a

2

4

1

1