Table 2 Disease gene coverage comparison. Comparison of the disease-related gene content in the top disease-annotated pathways from Table 1 based on matching reference gene sets available from Jensen DISEASES. Absolute gene counts together with percentage of DISEASES genes in parentheses are provided for each database-disease pair. The gene counts for the most represented disease per database is in bold italics. An average percentage of DISEASES genes per database is given in parentheses in column headers
From: Using published pathway figures in enrichment analysis and machine learning
Disease | PFOCR (63%) | Reactome (9%) | WikiPathways (21%) | KEGG (28%) |
|---|---|---|---|---|
Cardiomyopathy | 53 (62%) | 2 (2%) | 14 (16%) | 31 (36%) |
Diabetes mellitus | 31 (39%) | 2 (3%) | 15 (19%) | 18 (23%) |
Obesity | 45 (71%) | 4 (6%) | 8 (13%) | 12 (19%) |
Parkinson | 34 (64%) | 3 (6%) | 11 (21%) | 15 (28%) |
Prostate cancer | 23 (64%) | 2 (6%) | 6 (17%) | 5 (14%) |
Alzheimer | 18 (58%) | 9 (29%) | 9 (29%) | 9 (29%) |
Melanoma | 21 (70%) | 5 (17%) | 6 (20%) | 7 (23%) |
Lung cancer | 24 (86%) | 7 (25%) | 13 (46%) | 17 (61%) |
Breast cancer | 23 (92%) | 12 (48%) | 14 (56%) | 13 (52%) |
Hypertension | 7 (88%) | 2 (25%) | 3 (38%) | 3 (38%) |
Atherosclerosis | 5 (63%) | 1 (13%) | 0 (0%) | 3 (38%) |
Retinoblastoma | 2 (67%) | 0 (0%) | 1 (33%) | 1 (33%) |
Huntington | 1 (50%) | 0 (0%) | 1 (50%) | 1 (50%) |
Renal cell carcinoma | 1 (50%) | 0 (0%) | 0 (0%) | 0 (0%) |
Schizophrenia | 8 (50%) | 1 (6%) | 1 (6%) | 0 (0%) |
Multiple myeloma | 4 (50%) | 1 (13%) | 0 (0%) | 0 (0%) |
Tuberous sclerosis | 2 (100%) | 0 (0%) | 0 (0%) | 0 (0%) |