Table 1 Possible molecular mechanisms for the observed phenotypes

Inactive and Derepressing

I + D

ES^CcdB > 1.8 and ES^RelE < 1

Misfolded protein

Inactive and Repressing

I + R

ES^CcdB > 1.8 and ES^RelE > 1

Reduced translational efficiency

Hyperactive and Derepressing

H + D

ES^CcdB < 0.7 and ES^RelE < 1

Well folded, increased translational efficiency

Hyperactive and Repressing

H + R

ES^CcdB < 0.7 and ES^RelE > 1

Faster folding kinetics in vivo or slightly increased translational efficiency