Fig. 2

Characterisation of the E14.5 ATAC features. A. Distribution of the E14.5 ATAC features relative to the TSS (transcription start sites) of genes in mouse genome. X-axis shows cumulative percentage of features locating upstream or downstream of the TSS. Colors indicate distance intervals from TSS in kb. B. Count frequency of feature peak locations along the average profile of gene from TSS to TTS (5´- > 3´ direction). C. Bar chart of all E14.5 ATAC features (blue) annotated for the genomic position relative to genes. Random position (red) is the average proportion for randomly positioned features, calculated using 1000 random shuffles of peak locations, per annotation category. D. Overlap between the features in the E14.5 mouse forebrain, midbrain and hindbrain according to ENCODE (ENCODE cCREs) and the expression-filtered E14.5 ATAC features used in the downstream analysis. E. Genomic regions of the expression-filtered E14.5 ATAC features and their overlap with the ENCODE features (blue). The features not overlapping with the ENCODE features are shown in red