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Fig. 2 | BMC Genomics

Fig. 2

From: Profiles of global mutations in the human intercellular adhesion molecule-1 (ICAM-1) shed light on population-specific malaria susceptibility

Fig. 2

Mapping of ICAM-1 SNPs on the three-dimensional complexes of PfEMP1 DBLβ and ICAM-1 (A) A-type PfEMP1 (B) BC-type PfEMP1. ICAM-1 is colored grey blue and DBLβ is colored pink and shown as ribbon and transparent surface. Interacting residues of ICAM-1 are shown as red (SNP present) or green (no SNP) sticks and ICAM-1-interacting DBLβ residues are shown as blue sticks for A-type and BC-type (P. falciparum 3D7 and IT4var13 strains (PDB ID: 5MZA and 6S8U)). The high-frequency ICAM-1 mutations that lie away from the binding interface are shown as pink spheres. The common ICAM-1-binding residues between A-type and BC-type are encircled in a red box. ICAM-1 interacting subsites 1, 2 and 3 are marked for A-type PfEMP1.

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BMC Genomics

ISSN: 1471-2164

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