Fig. 3

Interactome of ICAM-1 and A-type/BC-type PfEMP1 DBLβ. ICAM-1 (Ig-like domains D1 and D2) and DBLβ are colored grey blue and pink respectively and shown as ribbons with transparent surface. ICAM-1 binding residues of A-type and BC-type are shown in pink boxes. The residues which show variation based on 145 predicted ICAM-1-binding DBLβ sequences [29] are marked with a red asterisk. DBLβ-interacting residues of ICAM-1 are shown in green or red boxes, no mutation and having mutation, respectively. The common ICAM-1 residues involved in interaction with both A-type and BC-type are underlined