Table 1 Results of MR between genetically predicted thyroid cancer (exposure, N = 1187) and breast cancer (outcome, N = 228,951), ER (+) breast cancer (outcome, N = 175,475), ER (-) breast cancer (outcome, N = 127,442)
Outcome | Analysis type | NSNP | Beta | SE | p value | Q | Q-p value | Egger intercept | Intercept-p value |
|---|---|---|---|---|---|---|---|---|---|
Breast Cancer | IVW (Random) | 328 | -9.204 × 10–4 | 4.046 × 10–4 | 0.023 | 567.222 | 3.683 × 10–15 | -4.123 × 10–4 | 0.638 |
IVW (Fixed) | 328 | -9.204 × 10–4 | 3.072 × 10–4 | 0.003 | 567.222 | 3.683 × 10–15 | |||
MR-Egger | 328 | -6.477 × 10–4 | 7.059 × 10–4 | 0.360 | 566.835 | 3.022 × 10–15 | |||
ER (+) | IVW (Random) | 328 | -1.203 × 10–3 | 4.663 × 10–4 | 0.010 | 529.97 | 7.990 × 10–12 | -1.116 × 10–3 | 0.268 |
IVW (Fixed) | 328 | -1.203 × 10–3 | 3.663 × 10–4 | 0.001 | 529.97 | 7.990 × 10–12 | |||
MR-Egger | 328 | -4.656 × 10–4 | 8.124 × 10–4 | 0.567 | 527.979 | 9.218 × 10–12 | |||
ER (-) | IVW (Random) | 328 | -4.559 × 10–4 | 6.368 × 10–4 | 0.474 | 426.033 | 1.825 × 10–4 | -3.149 × 10–5 | 0.982 |
IVW (Fixed) | 328 | -4.559 × 10–4 | 5.579 × 10–4 | 0.414 | 426.033 | 1.825 × 10–4 | |||
MR-Egger | 328 | -4.351 × 10–4 | 1.112 × 10–3 | 0.696 | 426.032 | 1.581 × 10–4 |