Unbalanced bidirectional causal association between thyroid cancer and ER-positive breast cancer: should we recommend screening for thyroid cancer in breast cancer patients?

Table 2 Results of MR between genetically predicted breast cancer (exposure, N = 228,951), ER (+) breast cancer (exposure, N = 175,475), ER (-) breast cancer (exposure, N = 127,442) and thyroid cancer (outcome, N = 1187)

Exposure	Analysis type	NSNP	Beta	SE	p value	Q	Q-p value	Egger intercept	Intercept-p value
Breast Cancer	IVW (Random)	62	0.324	0.234	0.167	86.118	0.019	-0.037	0.045
	IVW (Fixed)	62	0.324	0.197	0.101	86.118	0.019
	MR-Egger	62	0.908	0.761	0.237	85.192	0.018
ER (+)	IVW (Random)	47	0.516	0.220	0.019	50.724	0.293	0.014	0.050
	IVW (Fixed)	47	0.516	0.210	0.014	50.724	0.293
	MR-Egger	47	0.306	0.764	0.691	50.632	0.261
ER (-)	IVW (Random)	19	0.479	0.307	0.118	39.917	2.142 × 10^–3	0.084	0.089
	IVW (Fixed)	19	0.479	0.206	0.020	39.917	2.142 × 10^–3
	MR-Egger	19	-0.255	0.837	0.764	37.930	2.512 × 10^–3

Q and Q-p value represent the Cochran’s Q value and corresponding p value for estimated heterogeneity; Egger intercept and intercept-p value represent estimated pleiotropy effect and corresponding p value
IVW Inverse variant weighted

ISSN: 1471-2164