Fig. 3

Bonding signature and lung cancer prognosis. a. The expression signature of 88 genes in A549 human lung cancers is sufficient to predict the bonding history of serum donors. b. Heatmap of expression data in patients with primary lung cancer (TCGA dataset) for 75 out of 86 genes described in (a). Unsupervised hierarchical clustering discriminates two major clusters (indicated as A and B) and a third minor one (cluster U). KM plots for the patients of clusters A and B, as described in (b), exhibited significant differences in disease-free interval time (c) P = 0. 0153; Log-Rank, Mantel-Cox test), and progression-free interval (d) P = 0.0030; Log-Rank, Mantel-Cox test). Bar plots showing the primary diseases (e) P = 0.000032 chi-squared test) and primary outcome (f) P = 0.0037 chi-squared test) of the patients of clusters A and B, as described in (b). CR: Complete Remission; PR: Partial Remission; PD: Progressive Disease; SD: Stable Disease