Fig. 5

Proteomic studies. a. Unsupervised hierarchical clustering of 318 proteins’ abundance that was detected in the sera of bonded (B) and bond-disrupted (BD and DB) animals. The two groups of samples from bond-disrupted animals reflected the effects of the sera in spheroid formation (shown at the bottom; ref. 16). In DB1 and DB2 a notable effect in spheroid size was not detected, as opposed to BD1-3. b. Protein expression levels exhibited a significant difference between the bonded and bond-disrupted groups. Red bars indicate upregulated and blue bars downregulated proteins (P < 0.05; student’s t-test)