Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study

BMC Genomics

Table 1 Results of all MR analyses with causality

Name (id)	No.of SNP	pleiotropy test (p. value)	Cochrane's Q heterogeneity test(Q_pval)	MR method	p.val	OR	or_lci95	or_uci95
Genus Eubacteriumbrachygroup(id.11296)	11	0.758	0.600	ivw-fe	0.011	3.066	1.287	7.308
				MR Egger	0.707	1.873	0.079	44.533
				Simple mode	0.104	6.224	0.840	46.133
				Weighted mode	0.106	6.224	0.826	46.931
				Weighted median	0.007	4.969	1.554	15.890
Genus Anaerostipes(id.1991)	15	0.398	0.841	ivw-fe	0.011	0.145	0.033	0.642
				MR Egger	0.980	0.942	0.011	80.970
				Simple mode	0.361	0.205	0.008	5.490
				Weighted mode	0.364	0.237	0.012	4.809
				Weighted median	0.122	0.214	0.030	1.511
Genus Faecalibacterium(id.2057)	13	0.558	0.648	ivw-fe	0.005	0.156	0.043	0.565
				MR Egger	0.408	0.316	0.023	4.380
				Simple mode	0.090	0.052	0.002	1.207
				Weighted mode	0.150	0.159	0.015	1.658
				Weighted median	0.096	0.178	0.023	1.355
Genus Prevotella7(id.11182)	12	0.627	0.886	ivw-fe	0.006	0.340	0.158	0.732
				MR Egger	0.966	1.112	0.010	122.089
				Simple mode	0.112	0.215	0.038	1.231
				Weighted mode	0.792	0.812	0.179	3.686
				Weighted median	0.034	0.326	0.116	0.917
Family Ruminococcaceae(id.2050)	10	0.332	0.413	ivw-fe	0.001	0.058	0.011	0.304
				MR Egger	0.048	0.009	0.000	0.468
				Simple mode	0.545	0.296	0.007	13.148
				Weighted mode	0.317	0.171	0.007	4.495
				Weighted median	0.040	0.094	0.010	0.897

No.of SNP Number of SNPs being used as IVs., ivw-fe Fixed-effects inverse variance weighting, OR Odds Ratio; or_lci95-or_uci95, 95% confidence interval; Significant P. value was marked in red

ISSN: 1471-2164