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Fig. 2 | BMC Genomics

Fig. 2

From: Transcriptomic analysis of glucosidase II beta subunit (GluIIß) knockout A549 cells reveals its roles in regulation of cell adhesion molecules (CAMs) and anti-tumor immunity

Fig. 2

Quantitative RT-PCR validation of significant changes demonstrated by NGS data. 9 genes encoded for CAMs were chosen for verification and 8 genes were confirmed to be significantly decreased in all 3 GluIIß knockout clones (PD-L1, VCAN, CDH2, CDH4, ITGA4, ESAM, NECTIN3, CADM1) while PTPRF was significantly decreased only in 1 out of 3 clones compared to non-target transfected cells. Further investigation on the effect of GluIIß knockout on PD-L2 also demonstrated the significant impact on the down regulation of PD-L2

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BMC Genomics

ISSN: 1471-2164

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