Table 3 Pathways in A549 lung adenocarcinoma cells significantly upregulated by GluIIß knockout as identified by the KEGG enrichment analysis
No. | KEGG ID | DEG | Description | padj | geneName | Count |
|---|---|---|---|---|---|---|
1 | hsa04918 | Up | Thyroid hormone synthesis | 0.040819616 | ADCY5/GPX2/FXYD2/GPX3/PRKCB/PLCB1/TTR/ADCY9/HSPA5 | 9 |
2 | hsa04911 | Up | Insulin secretion | 0.030818158 | ADCY5/FXYD2/CACNA1D/PRKCB/KCNJ11/PLCB1/RAB3A/ADCY9/RAPGEF4/ABCC8 | 10 |
3 | hsa04970 | Up | Salivary secretion | 0.030818158 | ADCY5/MUC5B/FXYD2/CST4/PRKCB/CST2/PLCB1/PRKG1/CST1/ADCY9 | 10 |
4 | hsa02010 | Up | ABC transporters | 0.030818158 | ABCB5/ABCG2/ABCB1/ABCB4/ABCA2/ABCC4/ABCC8 | 7 |
5 | hsa04923 | Up | Regulation of lipolysis in adipocytes | 0.015700313 | ADCY5/NPY1R/IRS2/AQP7/PRKG1/PLIN1/ADORA1/ADCY9 | 8 |
6 | hsa00980 | Up | Metabolism of xenobiotics by cytochrome P450 | 0.013693988 | ADH1C/ADH6/UGT1A1/CYP1A1/ALDH3A1/UGT1A6/AKR1C1/EPHX1/CYP2S1 | 9 |
7 | hsa00360 | Up | Phenylalanine metabolism | 0.010209358 | DDC/HPD/ALDH3A1/TAT/MAOA | 5 |
8 | hsa00910 | Up | Nitrogen metabolism | 0.004642571 | CPS1/CA8/CA2/GLUL/CA13 | 5 |
9 | hsa00830 | Up | Retinol metabolism | 0.002769283 | ADH1C/ADH6/UGT1A1/CYP1A1/CYP26B1/UGT1A6/SDR16C5/RDH10/CYP2S1/ALDH1A1 | 10 |
10 | hsa04976 | Up | Bile secretion | 0.002769283 | ADCY5/FXYD2/CA2/NR1H4/ABCG2/SLC51B/ABCB1/ABCB4/ADCY9/EPHX1/ABCC4 | 11 |
11 | hsa04950 | Up | Maturity onset diabetes of the young | 0.001518883 | HNF4A/HNF1A/RFX6/FOXA3/HNF4G/BHLHA15/HHEX | 7 |
12 | hsa00350 | Up | Tyrosine metabolism | 0.001518883 | ADH1C/HGD/DDC/ADH6/HPD/ALDH3A1/TAT/MAOA | 8 |
13 | hsa04610 | Up | Complement and coagulation cascades | 0.000147849 | FGB/F5/FGG/FGA/F7/F2/PROC/F2RL2/CPB2/F13B/VTN/C5/TFPI/KNG1 | 14 |