Table 4 Pathways in A549 lung adenocarcinoma cells significantly downregulated by GluIIß knockout as identified by the KEGG enrichment analysis

1

hsa04060

Down

Cytokine-cytokine receptor interaction

1.64E-06

IL11/CXCL5/CXCL1/IL31RA/CXCL8/IL6/CSF3/CSF2/TNFSF14/CXCL3/CCL20/IL32/CXCL2/IL33/IL7R/TNFRSF19/BMP2/INHBA/CD70/IL1B/TNFRSF25/TNFRSF9/CCL2/NGF/IL1A/TGFB2/CRLF2/CCL26/IL24/PRLR/CSF2RA/PPBP/TGFB1

33

2

hsa04640

Down

Hematopoietic cell lineage

1.64E-06

ANPEP/IL11/IL6/CSF3/CSF2/ITGB3/IL7R/ITGA4/IL1B/IL1A/ITGA2/CD38/ITGA5/CD14/CSF2RA/CD55/CD44

17

3

hsa04512

Down

ECM-receptor interaction

4.11E-06

TNC/ITGB3/COL4A1/COL4A6/ITGA4/COL6A2/LAMC2/LAMA4/COL6A1/COL4A2/ITGA2/COL4A5/THBS1/ITGA5/SDC4/ITGB6/CD44/COL1A1

18

4

hsa05146

Down

Amoebiasis

6.04E-06

CXCL1/TLR4/CXCL8/IL6/CSF2/SERPINB3/COL4A1/COL4A6/SERPINB4/LAMC2/IL1B/LAMA4/PIK3CD/TGFB2/COL4A2/COL4A5/CD14/RAB7B/TGFB1/COL1A1

20

5

hsa04657

Down

IL-17 signaling pathway

1.29E-05

S100A9/CXCL5/CXCL1/CXCL8/IL6/CSF3/CSF2/TNFAIP3/CXCL3/CCL20/CXCL2/PTGS2/MMP1/LCN2/IL1B/CCL2/S100A8/FOSL1/JUN

19

6

hsa05323

Down

Rheumatoid arthritis

2.03E-05

IL11/CXCL5/CXCL1/TLR4/CXCL8/IL6/CSF2/CCL20/MMP1/IL1B/CCL2/IL1A/TGFB2/ICAM1/JUN/TGFB1

16

7

hsa05144

Down

Malaria

2.79E-05

TLR4/CXCL8/IL6/CSF3/IL1B/CCL2/TGFB2/ICAM1/THBS1/LRP1/TGFB1

11

8

hsa04668

Down

TNF signaling pathway

9.53E-05

CXCL5/CXCL1/IL6/CSF2/TNFAIP3/CXCL3/CCL20/CXCL2/SOCS3/PTGS2/IL1B/PIK3CD/CCL2/VEGFC/ICAM1/CREB5/JUN/TRAF1/RPS6KA5/BCL3

20

9

hsa04933

Down

AGE-RAGE signaling pathway in diabetic complications

0.000106817

SERPINE1/CXCL8/IL6/COL4A1/COL4A6/IL1B/STAT5A/MMP2/PIK3CD/CCL2/IL1A/TGFB2/COL4A2/COL4A5/VEGFC/ICAM1/JUN/TGFB1/COL1A1

19

10

hsa05205

Down

Proteoglycans in cancer

0.000126055

PLAU/TLR4/ANK1/ITGB3/WNT5A/CAV1/LUM/MMP2/PIK3CD/HOXD10/TGFB2/ITGA2/EGFR/THBS1/ITGA5/PLAUR/SDC4/TWIST1/FZD2/ITPR2/HBEGF/CAMK2A/CAMK2B/FGF2/CAV2/ITPR1/TGFB1/CD44

28

11

hsa04151

Down

PI3K-Akt signaling pathway

0.00020725

TNC/GNG2/TLR4/IL6/CSF3/FGF5/ITGB3/IL7R/COL4A1/COL4A6/ITGA4/EFNA1/COL6A2/LAMC2/LAMA4/PPP2R2B/COL6A1/SGK1/F2R/PIK3CD/NGF/COL4A2/ITGA2/COL4A5/VEGFC/FGF1/EGFR/CREB5/THBS1/ITGA5/PRLR/NTRK2/PDGFRA/GNGT2/ITGB6/FGF2/EFNA3/COL1A1

38

12

hsa04514

Down

Cell adhesion molecules (CAMs)

0.000897575

CDH4/CDH2/PDCD1LG2/VCAN/ITGA4/NLGN4Y/NEGR1/NRXN3/ESAM/CD274/ICAM1/PTPRF/CADM1/SDC4/NECTIN3/NLGN2/NFASC

17

13

hsa04360

Down

Axon guidance

0.000928331

UNC5D/EPHA5/SLIT3/EPHB2/RHOD/EFNA1/WNT5A/SEMA3F/EPHA4/NTN4/PIK3CD/EFNB2/ABLIM3/SEMA3A/SLIT2/EFNB3/NGEF/NRP1/PLXNB3/BOC/CAMK2A/CAMK2B/EFNA3/SEMA7A

24

14

hsa04926

Down

Relaxin signaling pathway

0.002116087

GNG2/NOS1/COL4A1/COL4A6/MMP1/MMP2/PIK3CD/SHC4/COL4A2/SHC3/COL4A5/VEGFC/EGFR/CREB5/JUN/ACTA2/GNGT2/TGFB1/COL1A1

19

15

hsa04510

Down

Focal adhesion

0.002118851

TNC/ITGB3/COL4A1/COL4A6/ITGA4/COL6A2/CAV1/LAMC2/LAMA4/COL6A1/PIK3CD/SHC4/COL4A2/SHC3/ITGA2/COL4A5/VEGFC/EGFR/THBS1/ITGA5/JUN/PDGFRA/ITGB6/CAV2/COL1A1

25

16

hsa05206

Down

MicroRNAs in cancer

0.003564802

TNC/PLAU/ZEB2/ITGB3/PTGS2/SOX4/FSCN1/HOXD10/TGFB2/SHC4/HMGA2/TPM1/TP63/EGFR/THBS1/ITGA5/BMF/RPS6KA5/PDGFRA/ZFPM2/EFNA3/CD44

22

17

hsa04974

Down

Protein digestion and absorption

0.006872919

COL5A1/COL13A1/COL4A1/COL4A6/KCNN4/COL6A2/COL7A1/COL6A1/COL4A2/COL4A5/COL17A1/COL1A1

12

18

hsa04630

Down

JAK-STAT signaling pathway

0.007649023

IL11/IL6/CSF3/CSF2/IL7R/SOCS3/STAT5A/PIK3CD/SOCS2/CRLF2/EGFR/IL24/AOX1/PRLR/CSF2RA/PDGFRA/IL22RA2

17

19

hsa05134

Down

Legionellosis

0.008413694

C3/CXCL1/TLR4/CXCL8/IL6/CXCL3/CXCL2/IL1B/HSPA2/CD14

10

20

hsa05132

Down

Salmonella infection

0.010368895

CXCL1/TLR4/CXCL8/IL6/CSF2/CXCL3/CXCL2/IL1B/IL1A/RILP/CD14/JUN/RAB7B

13

21

hsa04621

Down

NOD-like receptor signaling pathway

0.010379084

CXCL1/TLR4/CXCL8/IFI16/IL6/TNFAIP3/CXCL3/CXCL2/ANTXR1/IL1B/CTSB/CCL2/ANTXR2/NLRP1/GBP1/JUN/GBP2/ITPR2/ITPR1

19

22

hsa05200

Down

Pathways in cancer

0.01238625

GNG2/CTNNA2/CXCL8/IL6/FGF5/IL7R/BMP2/COL4A1/COL4A6/PTGS2/RUNX1/MMP1/WNT5A/LAMC2/STAT5A/LAMA4/F2R/MMP2/PIK3CD/TGFB2/COL4A2/PLEKHG5/ITGA2/GLI2/COL4A5/VEGFC/FGF1/RASGRP1/EGFR/BIRC7/JUN/FZD2/TRAF1/AXIN2/CSF2RA/RPS6KA5/PDGFRA/GNGT2/PPARG/NKX3-1/CAMK2A/CAMK2B/FGF2/ETS1/TGFB1

45

23

hsa05133

Down

Pertussis

0.018621623

CXCL5/C3/TLR4/CXCL8/IL6/IL1B/IL1A/C1R/ITGA5/CD14/JUN

11

24

hsa05143

Down

African trypanosomiasis

0.028554735

IL6/IL1B/LAMA4/F2RL1/APOL1/ICAM1

6

25

hsa04145

Down

Phagosome

0.028742909

C3/OLR1/TLR4/NOS1/ITGB3/SFTPD/CTSS/RILP/ITGA2/TUBA1A/C1R/THBS1/ITGA5/CD14/RAB7B

15

26

hsa04020

Down

Calcium signaling pathway

0.029706359

NOS1/DRD1/NTSR1/F2R/ADRB2/HRH1/CD38/ADRB1/EGFR/RYR3/PTAFR/PDGFRA/ITPR2/SPHK1/CAMK2A/CAMK2B/GRIN2C/ITPR1

18

27

hsa05410

Down

Hypertrophic cardiomyopathy (HCM)

0.030147705

IL6/ITGB3/ITGA4/TGFB2/ITGA2/SGCD/TPM1/DMD/ITGA5/ITGB6/TGFB1

11

28

hsa05140

Down

Leishmaniasis

0.031475877

C3/TLR4/ITGA4/PTGS2/IL1B/IL1A/TGFB2/JUN/TGFB1

9

29

hsa04064

Down

NF-kappa B signaling pathway

0.032287711

BCL2A1/PLAU/TLR4/CXCL8/TNFAIP3/TNFSF14/CXCL2/PTGS2/IL1B/ICAM1/CD14/TRAF1

12

30

hsa05414

Down

Dilated cardiomyopathy (DCM)

0.038511016

ITGB3/ITGA4/TGFB2/ITGA2/SGCD/TPM1/ADRB1/DMD/ITGA5/ITGB6/TGFB1

11

31

hsa05412

Down

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

0.040130882

CTNNA2/CDH2/ITGB3/ITGA4/ITGA2/SGCD/DMD/ITGA5/GJA1/ITGB6

10

32

hsa05142

Down

Chagas disease (American trypanosomiasis)

0.040130882

C3/SERPINE1/TLR4/CXCL8/IL6/IL1B/PPP2R2B/PIK3CD/CCL2/TGFB2/JUN/TGFB1

12

33

hsa04060

Down

Cytokine-cytokine receptor interaction

1.64E-06

IL11/CXCL5/CXCL1/IL31RA/CXCL8/IL6/CSF3/CSF2/TNFSF14/CXCL3/CCL20/IL32/CXCL2/IL33/IL7R/TNFRSF19/BMP2/INHBA/CD70/IL1B/TNFRSF25/TNFRSF9/CCL2/NGF/IL1A/TGFB2/CRLF2/CCL26/IL24/PRLR/CSF2RA/PPBP/TGFB1

33