Table 3 The top 10 DEGs in each cell cluster between control and PAH group
cluster | p_val | avg_log2FC | pct.1 | pct.2 | p_val_adj | gene |
|---|---|---|---|---|---|---|
NK cells | 3.23E-57 | 2.07039378 | 0.952 | 0.339 | 6.32E-53 | GZMB |
NK cells | 4.92E-50 | 2.0951293 | 0.722 | 0.064 | 9.63E-46 | SFTPC |
NK cells | 1.60E-46 | 2.04057065 | 0.78 | 0.133 | 3.14E-42 | FGFBP2 |
NK cells | 8.08E-34 | 1.62372396 | 0.738 | 0.202 | 1.58E-29 | SPON2 |
NK cells | 5.62E-29 | 1.46648213 | 0.759 | 0.292 | 1.10E-24 | HOPX |
NK cells | 2.47E-22 | 1.79013003 | 0.347 | 0.009 | 4.83E-18 | S100A8 |
NK cells | 4.38E-21 | 1.50916294 | 0.392 | 0.039 | 8.57E-17 | S100A9 |
NK cells | 1.65E-20 | 2.35866194 | 0.37 | 0.039 | 3.23E-16 | PTGDS |
NK cells | 4.32E-19 | 1.80928128 | 0.286 | 0 | 8.45E-15 | PLA2G2A |
NK cells | 4.38E-08 | 1.38693313 | 0.799 | 0.742 | 0.00085751 | CCL3 |
Macrophages | 4.67E-280 | 4.03072278 | 0.77 | 0 | 9.15E-276 | ATP5E |
Macrophages | 4.20E-278 | 3.95218871 | 0.765 | 0 | 8.22E-274 | GPX1 |
Macrophages | 2.48E-270 | 3.22972958 | 0.747 | 0 | 4.85E-266 | GNB2L1 |
Macrophages | 2.95E-250 | 2.89671615 | 0.7 | 0 | 5.78E-246 | ATP5L |
Macrophages | 5.45E-239 | 2.66855548 | 0.673 | 0 | 1.07E-234 | C14orf2 |
Macrophages | 2.78E-223 | 2.64832443 | 0.634 | 0 | 5.45E-219 | TCEB2 |
Macrophages | 2.08E-137 | 3.4251223 | 0.411 | 0 | 4.07E-133 | SEPP1 |
Macrophages | 1.86E-113 | 3.58695812 | 0.53 | 0.07 | 3.65E-109 | CCL2 |
Macrophages | 9.23E-66 | 2.85414508 | 0.359 | 0.053 | 1.81E-61 | FABP4 |
Macrophages | 3.97E-43 | 2.54189771 | 0.474 | 0.202 | 7.78E-39 | CD524 |
Fibroblasts | 2.28E-100 | 3.61565966 | 0.845 | 0 | 4.46E-96 | GNB2L17 |
Fibroblasts | 3.82E-92 | 4.6633342 | 0.863 | 0.077 | 7.47E-88 | PLA2G2A8 |
Fibroblasts | 8.51E-92 | 3.07543157 | 0.804 | 0 | 1.67E-87 | SELM6 |
Fibroblasts | 1.74E-90 | 2.69884577 | 0.948 | 0.244 | 3.42E-86 | CFD8 |
Fibroblasts | 1.34E-87 | 2.85203685 | 0.783 | 0 | 2.62E-83 | ATP5E7 |
Fibroblasts | 4.21E-73 | 2.7374571 | 0.827 | 0.179 | 8.24E-69 | MFAP55 |
Fibroblasts | 7.35E-72 | 2.68411819 | 0.812 | 0.145 | 1.44E-67 | SLPI8 |
Fibroblasts | 1.74E-68 | 2.59723614 | 0.831 | 0.192 | 3.41E-64 | APOD6 |
Fibroblasts | 4.53E-61 | 2.65393169 | 0.745 | 0.141 | 8.87E-57 | RARRES1 |
Fibroblasts | 3.16E-44 | 2.60853672 | 0.535 | 0.026 | 6.18E-40 | HAS1 |
Monocytes | 7.36E-248 | 3.58327494 | 0.634 | 0 | 1.44E-243 | ATP5E6 |
Monocytes | 4.65E-239 | 3.28083274 | 0.618 | 0 | 9.10E-235 | GNB2L16 |
Monocytes | 1.03E-232 | 3.65768818 | 0.607 | 0 | 2.02E-228 | GPX16 |
Monocytes | 7.81E-213 | 2.67403707 | 0.569 | 0 | 1.53E-208 | ATP5L6 |
Monocytes | 1.44E-185 | 2.47998988 | 0.514 | 0 | 2.82E-181 | C14orf26 |
Monocytes | 8.57E-169 | 3.59846333 | 0.763 | 0.311 | 1.68E-164 | S100A97 |
Monocytes | 5.30E-140 | 3.81550818 | 0.639 | 0.191 | 1.04E-135 | S100A87 |
Monocytes | 2.25E-111 | 3.17127943 | 0.343 | 0 | 4.40E-107 | CCL3L31 |
Monocytes | 1.87E-75 | 2.81840302 | 0.313 | 0.042 | 3.65E-71 | CCL26 |
Monocytes | 6.94E-71 | 3.46351087 | 0.332 | 0.063 | 1.36E-66 | S100A12 |
Epithelial_cells | 8.08E-16 | 2.60617797 | 0.712 | 0 | 1.58E-11 | GKN2 |
Epithelial_cells | 1.49E-15 | 4.06737565 | 0.77 | 0.085 | 2.92E-11 | PGC |
Epithelial_cells | 3.32E-13 | 2.03992994 | 0.845 | 0.298 | 6.49E-09 | NAPSA |
Epithelial_cells | 1.34E-12 | 2.62868014 | 0.809 | 0.404 | 2.62E-08 | SFTPA26 |
Epithelial_cells | 1.90E-12 | 1.91495198 | 0.835 | 0.255 | 3.73E-08 | SFTPD |
Epithelial_cells | 2.83E-11 | 2.06833734 | 0.835 | 0.383 | 5.55E-07 | SFTPA15 |
Epithelial_cells | 1.58E-07 | 2.50721409 | 0.406 | 0 | 0.0030941 | GNB2L15 |
Epithelial_cells | 3.73E-07 | 2.29401564 | 0.388 | 0 | 0.0073072 | ATP5E5 |
Epithelial_cells | 7.30E-07 | 1.83558137 | 0.374 | 0 | 0.01428215 | ATP5L5 |
Epithelial_cells | 2.25E-05 | 1.98895129 | 0.295 | 0 | 0.4404569 | FGG |
Endothelial_cells | 8.84E-45 | 2.37517579 | 0.525 | 0.056 | 1.73E-40 | SLPI5 |
Endothelial_cells | 2.61E-28 | 2.49810917 | 0.316 | 0 | 5.11E-24 | GNB2L14 |
Endothelial_cells | 6.41E-28 | 2.02900096 | 0.352 | 0.023 | 1.26E-23 | S100A85 |
Endothelial_cells | 6.67E-28 | 2.18205705 | 0.312 | 0 | 1.31E-23 | ATP5E4 |
Endothelial_cells | 1.61E-25 | 1.77403574 | 0.345 | 0.033 | 3.16E-21 | S100A95 |
Endothelial_cells | 1.60E-16 | 2.21981929 | 0.194 | 0 | 3.13E-12 | C10orf103 |
Endothelial_cells | 2.25E-13 | 1.96717524 | 0.157 | 0 | 4.40E-09 | CA4 |
Endothelial_cells | 5.31E-10 | 2.72216931 | 0.218 | 0.062 | 1.04E-05 | FCN3 |
Endothelial_cells | 2.81E-08 | 1.82344434 | 0.137 | 0.023 | 0.00054916 | IL1RL1 |
Endothelial_cells | 3.70E-08 | 1.78576199 | 0.147 | 0.03 | 0.00072335 | HPGD |
Chondrocytes | 4.41E-91 | 3.92030676 | 0.815 | 0 | 8.64E-87 | SELM2 |
Chondrocytes | 1.11E-89 | 3.22559095 | 0.805 | 0 | 2.17E-85 | GNB2L13 |
Chondrocytes | 7.48E-85 | 3.18022527 | 0.771 | 0 | 1.46E-80 | ATP5E3 |
Chondrocytes | 3.46E-76 | 3.02854454 | 0.707 | 0 | 6.77E-72 | PRKCDBP2 |
Chondrocytes | 2.07E-70 | 2.8402306 | 0.663 | 0 | 4.04E-66 | SEPW12 |
Chondrocytes | 1.17E-61 | 4.40187507 | 0.722 | 0.075 | 2.29E-57 | CFD4 |
Chondrocytes | 1.89E-52 | 3.67716374 | 0.527 | 0.003 | 3.69E-48 | PLA2G2A4 |
Chondrocytes | 2.62E-33 | 3.14176007 | 0.512 | 0.083 | 5.13E-29 | FBLN13 |
Chondrocytes | 1.80E-16 | 2.53079619 | 0.288 | 0.051 | 3.52E-12 | SFRP22 |
Chondrocytes | 8.36E-15 | 2.6062608 | 0.195 | 0.013 | 1.64E-10 | S100A84 |
CD8+ T-cells | 6.49E-256 | 2.48007975 | 0.628 | 0.061 | 1.27E-251 | SFTPC3 |
CD8+ T-cells | 6.42E-217 | 1.79380393 | 0.318 | 0.01 | 1.26E-212 | S100A83 |
CD8+ T-cells | 2.04E-147 | 1.2227903 | 0.202 | 0.005 | 4.00E-143 | PLA2G2A3 |
CD8+ T-cells | 6.46E-73 | 1.12580015 | 0.265 | 0.037 | 1.26E-68 | SCGB1A13 |
CD8+ T-cells | 2.84E-66 | 1.32786131 | 0.298 | 0.052 | 5.56E-62 | S100A93 |
CD8+ T-cells | 9.02E-46 | 1.04286872 | 0.369 | 0.105 | 1.77E-41 | PRF11 |
CD8+ T-cells | 7.02E-43 | 1.86545565 | 0.336 | 0.1 | 1.38E-38 | GZMB1 |
CD8+ T-cells | 8.10E-30 | 1.01438835 | 0.301 | 0.1 | 1.58E-25 | CFD3 |
CD8+ T-cells | 2.45E-19 | 1.10154655 | 0.595 | 0.39 | 4.80E-15 | NKG71 |
CD8+ T-cells | 0.00369386 | 3.86973914 | 0.113 | 0.068 | 1 | HBB1 |
CD4+ T-cells | 9.14E-39 | 2.45943115 | 0.63 | 0.052 | 1.79E-34 | SFTPC2 |
CD4+ T-cells | 8.64E-27 | 2.68921472 | 0.301 | 0 | 1.69E-22 | GNB2L12 |
CD4+ T-cells | 1.37E-25 | 2.32625235 | 0.288 | 0 | 2.68E-21 | ATP5E2 |
CD4+ T-cells | 3.31E-23 | 2.0635857 | 0.26 | 0 | 6.48E-19 | ATP5L2 |
CD4+ T-cells | 2.50E-17 | 1.55626068 | 0.192 | 0 | 4.89E-13 | GLTSCR22 |
CD4+ T-cells | 6.26E-17 | 1.37413653 | 0.233 | 0.008 | 1.23E-12 | S100A82 |
CD4+ T-cells | 2.66E-15 | 1.72645498 | 0.384 | 0.069 | 5.21E-11 | IGFBP62 |
CD4+ T-cells | 5.22E-15 | 1.31327107 | 0.164 | 0 | 1.02E-10 | ATP5G22 |
CD4+ T-cells | 2.95E-11 | 1.54092574 | 0.384 | 0.099 | 5.78E-07 | DCN2 |
CD4+ T-cells | 2.06E-10 | 1.35530821 | 0.356 | 0.091 | 4.02E-06 | CFD2 |
Adipocytes | 1.57E-180 | 3.44999227 | 0.76 | 0 | 3.08E-176 | GNB2L11 |
Adipocytes | 3.29E-166 | 3.7989569 | 0.83 | 0.128 | 6.44E-162 | PLA2G2A1 |
Adipocytes | 7.83E-165 | 3.19946236 | 0.721 | 0 | 1.53E-160 | SELM1 |
Adipocytes | 3.95E-160 | 2.86553955 | 0.709 | 0 | 7.73E-156 | ATP5E1 |
Adipocytes | 2.64E-127 | 2.25769098 | 0.617 | 0 | 5.17E-123 | ATP5L1 |
Adipocytes | 2.84E-125 | 2.2359181 | 0.611 | 0 | 5.56E-121 | C14orf21 |
Adipocytes | 6.09E-123 | 2.20576993 | 0.604 | 0 | 1.19E-118 | TCEB21 |
Adipocytes | 1.03E-99 | 2.28601276 | 0.527 | 0 | 2.01E-95 | SEPP11 |
Adipocytes | 6.50E-93 | 2.10602684 | 0.503 | 0 | 1.27E-88 | PRKCDBP1 |
Adipocytes | 1.39E-47 | 2.24942588 | 0.306 | 0 | 2.72E-43 | C10orf101 |