Fig. 1

Ribosomal profiling reveals active translation of HERV proviruses in healthy tissue and cell types. a Schematic overview of workflow for profiling HERV proviral abundances from RiboSeq data. b HERV-aligned reads as a percentage of all filtered sequencing reads per sample. Dots indicate individual biological replicates with the graphed mean. Error bars indicate ± standard error of the mean (SEM). c Sum number of HERV proviruses possessing ≥1RPM per sample. Dots indicate individual biological replicates with the graphed mean. Error bars indicate ± SEM. d PCA plot of all tissue and cell types based on HERV-aligned ribosomal profiling reads alone. e Individual sample RPM abundances of all HERV proviruses per sample clustered per cell or tissue type. HERVs are listed in descending order by average RPM abundance. f Average RPM abundances of all HERV proviruses per cell or tissue type. HERVs are listed in descending order by average RPM abundance