Table 1 A description of the available data in the DISNET platform used in this study
Description | DISNET layer | Count | Identifiers | Sources | Access date | ||
|---|---|---|---|---|---|---|---|
Entities | Diseases | Data representing diseases | Phenotypical | 15,415 | DISNET own identifiers | Wikipedia Mayo Clinic PubMed | February 2018 – September 2022 (twice a month) |
Biological | 24,314 | UMLS CUIs | DisGeNET | May 2020 | |||
Drugs | 8366 | UMLS CUIs | CTD | May 2020 | |||
Symptoms | Data representing symptoms and phenotypical effects | Phenotypical | 26,257 | UMLS CUIs | Wikipedia Mayo Clinic PubMed | February 2018 – September 2022 (twice a month) | |
Drugs | 3944 | UMLS CUIs | ChEMBL | May 2020 | |||
Genes | Data representing genes | Biological | 20,610 | NCBI identifiers | DisGeNET | May 2020 | |
Pathways | Data representing pathways | Biological | 1105 | WikiPathways | WikiPathways | May 2022 | |
Proteins and Targets | Data representing proteins and drug targets | Biological | 18,521 | UniProt Accession Numbers | UniProt | May 2020 | |
Drugs | 13,382 | ChEMBL identifiers | ChEMBL | May 2020 | |||
Drugs | Data representing drugs of different molecular types | Drugs | 3944 | ChEMBL identifiers | ChEMBL | May 2020 | |
2540 | DrugBank identifiers | DrugBank | May 2020 | ||||
Relationships | Disease - Gene | Associations between diseases and their related genes | Biological | 358,209 | – | DisGeNET | May 2020 |
Disease - Symptom | Associations between diseases and their related symptoms | Phenotypical | 201,541 | – | Wikipedia Mayo Clinic PubMed | February 2018 – September 2022 (twice a month) | |
Disease -Pathway | Associations between diseases and their related pathways | Biological | 664 | – | WikiPathways | Jun 2022 | |
Pathway-gene | Associations between pathways and their related genes | Biological | 11,732 | – | WikiPathways | May 2022 | |
Gene - Protein | Associations between genes and the proteins they encode | Biological | 15,770 | – | DisGeNET | May 2020 | |
Drug - Disease | Associations between diseases that are indications for drugs and drugs | Drugs | 1,218,607 | – | CTD | May 2020 | |
Drug - Target | Associations between targets to which drugs are directed and drugs | Drugs | 7902 | – | ChEMBL | May 2020 | |
DrugBank | May 2020 |