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Fig. 2 | BMC Genomics

Fig. 2

From: Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells

Fig. 2

SC-β cells derived from different protocols possess similar transcriptional profiles relative to adult β cells, see also Fig. S3 & Table S3. a UMAP of adult β-cells, fetal β-cells, and SC β-cells clustered and split by their derivation protocol. b Heatmap of Pearson correlation coefficient for 1000 most variable expressed genes in β-cells. c Heatmap indicating average expression of β-cell maturation markers. d Heatmap of scaled RNA expression indicating top 20 most differentially expressed genes for β-cells derived by unique protocols, fetal β-cells, and adult β-cells. e UMAP of SC-EC cells clustered and split by their derivation protocol. f Heatmap of Pearson correlation coefficient for 1000 most variable expressed genes in SC-EC cells. g Violin plots indicating expression level of SC-EC identity markers across derivation protocols. h Heatmap of scaled RNA expression indicating top 20 most differentially expressed genes for SC-EC cells across protocols

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BMC Genomics

ISSN: 1471-2164

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