Fig. 4
Assessment of reproducibility of methylation values at lower input levels than recommended by the manufacturer. Correlation plots of the methylation β-value of PrEC technical replicates with varying DNA input levels at a) 500 ng, b) 250 ng and c) 125 ng. d) Number of probes with detection p-value > 0.05 in PrEC technical replicates with varying DNA input levels. e) DNA methylation of prostate cancer tissue and cell line samples (of varying DNA input levels) at new EPICv2 sites overlapping newly targeted FANTOM5 prostate specific enhancer (black box) and nearby gene promoter showing inverse methylation between sample types (blue box)