Fig. 7
From: The impact of selective HDAC inhibitors on the transcriptome of early mouse embryos
Relationship between the genes affected by HDACi and their epigenetic status. The dot heatmap shows the enrichment of DEGs that are up- or downregulated by the two HDACi at the 1-cell, 2-cell, and 4-cell stage, respectively, in the defined gene set, which exhibited high-level epigenetic modifications in the promoter region. The size of the dots/open circles (outer) represent the negative logarithm of the P-value adjusted for multiple testing in the hypergeometric test. An open circle denotes an adjusted P-value < 0.01, indicating a significant enrichment effect; otherwise, a point is used to indicate no significant enrichment. The color indicates the number of genes affected by HDACi in the defined high-level epigenetically modified gene set