Table 3 Top 20 diverse proteins (as determined by coding nucleotide diversity) of Biomphalaria sudanica that contain at least one transmembrane domain, and thus represent putative pathogen recognition receptors. * Non-truncated BSUD.4885 protein is 405 aa in length as determined by manual alignment
Gene (contig/scaffold, Linkage Group) | Nucleotide Diversity % (coding) | Protein length (aa) | Inferred protein-receptor function / functional domains / protein family |
|---|---|---|---|
BSUD.20937 (80, LG1) | 5.7 | 453 | Tumor Necrosis Factor (TNF) |
BSUD.4884 (2266, LG10) | 5.3 | 86 | Unknown, linked (same contig) to RADres [79]. Bacteriocin domain |
BSUD.4885 (2266, LG10) | 4.8 | 354* | Unknown, linked (same contig) to RADres [79]. Domains: TMEM154 protein family, Rifin |
BSUD.3983 (208, LG16) | 4.0 | 817 | Unknown, linked (same contig) to PTC2 [42]. Domains: SHP2-interacting transmembrane adaptor protein, SIT |
BSUD.4096 (208, LG16) | 3.7 | 270 | Unknown, linked (same contig) to PTC2 [42]. Domains: Viral glycoprotein L |
BSUD.20268 (7608, LG6) | 3.3 | 75 | Unknown. Domains of unknown function (DUF6768) |
BSUD.9255 (379, LG11) | 3.3 | 453 | Unknown Domains of unknown function (DUF4781), Death domain |
BSUD.15077 (580, LG16) | 3.1 | 318 | Cell adhesion molecule. Wnt and fibroblast growth factor (FGF) inhibitory regulator and Protocadherin domain. |
BSUD.4112 (208, LG16) | 2.9 | 341 | Cell adhesion molecule linked (same contig) to PTC2 [42]. Protocadherin domain. |
BSUD.18104 (69, LG15) | 2.8 | 1154 | G-protein coupled receptor. 7 transmembrane receptor (rhodopsin family), Leucine-rich repeat |
BSUD.3984 (208, LG16) | 2.7 | 324 | Polymorphic transmembrane cluster 2 (PTC2) gene 9 [42]. |
BSUD.14211 (540, LG5) | 2.7 | 516 | Cell adhesion molecule. F5/8 type C domain. |
BSUD.17807 (6862, LG13) | 2.7 | 504 | Cell adhesion molecule. Ephrin type-A receptor 2 transmembrane and immunoglobulin domain. |
BSUD.14415 (550, LG16) | 2.6 | 483 | Unknown. Wolframin EF-hand domain |
BSUD.9838 (3979, LG4) | 2.6 | 203 | Transient receptor potential cation channel subfamily M member 2-like. Ion transport domain |
BSUD.12903 (499, LG16) | 2.6 | 647 | Receptor with C-type lectin and immunoglobulin domain |
BSUD.23928 (4388, LG10) | 2.5 | 944 | G-protein coupled receptor. 7 transmembrane receptor (rhodopsin family), Low-density lipoprotein receptor domain class A, Leucine-rich repeat |
BSUD.8884 (359, LG6) | 2.4 | 565 | Guadeloupe Resistance Complex (GRC/PTC1) gene 2 [41, 80]. Fibronectin type III domain, TMEM154 protein family. |
BSUD.4003 (208, LG16) | 2.4 | 473 | Unknown, linked (same contig) to PTC2 [42]. Prodomain subtilisin 2, TMEM154 protein family. |
BSUD.4089 (208, LG16) | 2.3 | 331 | Receptor with C-type lectin domain. |