Table 4 Top 10 drug/compound candidates predicted using DSigDB
From: Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
Term | P-value | Adjusted P-value | Old P-value | Old Adjusted P-value | Odds Ratio | Combined Score | Genes |
SC-560 MCF7 DOWN | 0.00479166 | 0.071879604 | 0 | 0 | 289.4637681 | 1545.990778 | GDI2 |
58-64-0 CTD 00005321 | 0.005588597 | 0.071879604 | 0 | 0 | 246.5308642 | 1278.762253 | TYRO3 |
caffeic acid PC3 DOWN | 0.005787756 | 0.071879604 | 0 | 0 | 237.7142857 | 1224.706508 | GDI2 |
CI-1033 Kinome Scan | 0.006185986 | 0.071879604 | 0 | 0 | 221.8444444 | 1128.183024 | TYRO3 |
promethazine PC3 DOWN | 0.008970245 | 0.071879604 | 0 | 0 | 151.1515152 | 712.50441 | GDI2 |
AZD-2171 Kinome Scan | 0.009168896 | 0.071879604 | 0 | 0 | 147.7851852 | 693.3989792 | TYRO3 |
methylergometrine PC3 DOWN | 0.009367518 | 0.071879604 | 0 | 0 | 144.5652174 | 675.1928734 | GDI2 |
domperidone MCF7 DOWN | 0.009764672 | 0.071879604 | 0 | 0 | 138.5277778 | 641.2429069 | GDI2 |
CP-863187 PC3 DOWN | 0.009963204 | 0.071879604 | 0 | 0 | 135.6938776 | 625.3936139 | GDI2 |
Cabozantinib FDA | 0.009963204 | 0.071879604 | 0 | 0 | 135.6938776 | 625.3936139 | TYRO3 |