SNP-based and haplotype-based genome-wide association on drug dependence in Han Chinese

BMC Genomics

Table 1 Genome-wide significant associations detected using hapQTL

SNP ID	Chr	Position	Gene	BF₂	p₂	BF₁	p₁
Only detected by single SNP test
rs3782886	12	112,110,489	BRAP	4.131	5.768	8.726*	10.315
rs671	12	112,241,766	ALDH2	3.443	5.231	7.406*	9.030
Only detected by haplotype test
rs9606757	22	31,016,645	TCN2	6.077*	9.259	−0.493	0.463
rs147307448	22	31,043,537	SLC35E4	7.607*	10.476	3.896	6.497
rs140377384	22	31,116,387	OSBP2	6.768*	10.017	0.344	2.049
Detected by both single SNP and haplotype tests
rs29243	6	29,599,102	GABBR1	10.702*	12.379	11.548*	12.556
rs6937645	6	29,828,584	HLA-H	7.322*	8.160	6.005*	7.267
rs1431403	6	33,047,031	HLA-DPA1	7.023*	7.764	6.881*	9.814
rs3130188	6	33,057,176	HLA-DPB1	20.925*	23.685	15.135*	17.977

The leading core SNPs of each gene in this region were listed above. BF₂ and p₂ are log₁₀BF and -log₁₀p for haplotype test, and BF₁ and p1 are log₁₀BF and -log₁₀p for single SNP test, respectively. The threshold for both BF₂ and BF₁ to declare genome-wide significant associations is 6, and * denotes genome-wide significant. The coordinates are from NCBI Build 37

ISSN: 1471-2164