Fig. 7

Correlated analysis of transcriptomic and metabolomic profiling of GCs from DMSO and MLN4924 treatment. A Heat map displaying the correlation between all DEGs and DAMs. Each row represents a differential metabolite, and each column represents a differential gene. Red indicates a positive correlation, blue indicates a negative correlation, and the darker the color, the stronger the correlation. Significant correlations are marked by an asterisk (*) to denote (P < 0.05). B Venn diagram illustrating shared KEGG terms among transcriptome and metabolome. The number in the blue circles indicates the number of KEGG signaling pathways for DEGs, the number in the orange circles indicates the number of KEGG signaling pathways for DAMs, and the overlapping sections show the number of pathways in which both omics are involved. C Correlation network of DEGs and DAMs related to lipids. Pink circles indicate lipid-related metabolites. Orange represents the DAMs involved in these metabolites. D Correlation network of DEGs and DAMs related to glucose. Pink indicates metabolites related to glucose metabolism, and orange indicates DEGs related to these metabolites