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Fig. 3 | BMC Genomics

Fig. 3

From: Identification and validation of RNA-binding protein SLC3A2 regulates melanocyte ferroptosis in vitiligo by integrated analysis of single-cell and bulk RNA-sequencing

Fig. 3

Single-cell analysis revealed heterogeneity and regulatory module of cell-specific RBPs in healthy donors and patients with vitiligo. (A) UMAP plot of scRNA-seq profile. Cells are colored according to cell clusters based on RBP-expression module. (B) Stacked bar plot showing relative proportions of cell populations based on RBP-expression module in keratinocytes, Langerhans, and melanocytes. (C) Unsupervised clustering heatmap showing relative expression (z score, row scaled) levels of top 5 representative markers in each cell population based on RBP-expression model. (D) Gene Ontology enrichment analysis of biological processes of top 50 marker genes of each cell type. Top three terms were selected for each cluster, and heatmap shows enrichment q-value of these terms (scaled by column). (E) Gene Ontology biological process of top 50 marker genes in Fig. 2D cluster8 based on RBP-expression module. (F) Dot plot showing expression of eight RBPs involved in apoptotic and immune system process terms from D in melanocytes. Dot color represents mean expression in each cluster; dot size indicates the percentage of cells expressing marker genes in each cluster

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BMC Genomics

ISSN: 1471-2164

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