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Fig. 6 | BMC Genomics

Fig. 6

From: Identification and validation of RNA-binding protein SLC3A2 regulates melanocyte ferroptosis in vitiligo by integrated analysis of single-cell and bulk RNA-sequencing

Fig. 6

Downregulation of SLC3A2 results in obvious oxidative damage and relates to melanocyte ferrocytosis. (A) Expression level of SLC3A2 was reduced, and SLC3A2 was downregulated in SLC3A2-interference group. Gel images were cropped for display. (B) Inhibition of melanocytes in G1 phase after SLC3A2 interference. (C) SLC3A2-interference group showed significant decrease in cell proliferation rate and significant increase in apoptosis rate and ROS content. In the SLC3A2-interference group, contents of Fe2+, MDA, GSH, and GPX4 expression in melanocytes increased, and SOD activity and TYR and COX2 expression levels decreased. Note: SLC3A2-interference vs. control, **: P < 0.01, ***: P < 0.001; SLC3A2-interference vs. SLC3A2-interference NC, ##: P < 0.01, ###: P < 0.001

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BMC Genomics

ISSN: 1471-2164

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