Table 4 Gene ontology showing enriched biological processes, molecular functions, and cellular components of whole blood innate and adaptive immune genes in low- compared with high-RFI steers1
| Â | Gene(s) | Raw P-value | FDR2 |
|---|---|---|---|
GO biological process | Â | Â | Â |
Detection of lipopolysaccharide | LY96 | 3.54E-06 | 1.70E-03 |
Positive regulation of interleukin-23 production | CSF2, IL17A | 4.55E-06 | 2.12E-03 |
Positive regulation of interleukin-17 production | IL2, IL15 | 2.65E-05 | 7.34E-03 |
Macrophage differentiation | IL15, CSF2 | 2.65E-05 | 7.20E-03 |
Toll-like receptor 4 signaling pathway | LY96 | 3.19E-05 | 8.36E-03 |
Positive regulation of tyrosine phosphorylation of STAT protein | IL2, IL15, CSF2 | 6.79E-07 | 6.52E-04 |
Receptor signaling pathway via JAK-STAT | IL15, CSF2 | 7.06E-05 | 1.43E-02 |
Defense response to fungus | MPO, IL17A | 8.37E-05 | 1.59E-02 |
Positive regulation of tumor necrosis factor production | LY96, IL17A | 2.01E-06 | 1.16E-03 |
Pattern recognition receptor signaling pathway | LY96, MBL2 | 2.58E-06 | 1.38E-03 |
Positive regulation of phagocytosis | IL15, MBL2 | 2.00E-04 | 3.31E-02 |
GO molecular function | Â | Â | Â |
Toll-like receptor 4 binding | LY96 | 1.90E-06 | 1.42E-03 |
Lipopolysaccharide immune receptor activity | LY96 | 3.54E-06 | 1.99E-03 |
Pattern recognition receptor activity | LY96, MBL-2 | 2.91E-05 | 1.31E-02 |
GO cellular component | Â | Â | Â |
Lipopolysaccharide receptor complex | LY96 | 4.55E-06 | 2.85E-03 |