Table 5 Gene ontology showing enriched biological processes, molecular functions, and cellular components of hepatic innate and adaptive immune genes in low- compared with high-RFI steers¹

GO biological process

Positive regulation of immunoglobulin production

IL13, IL6, TBX21, IL4, IL

1.23E-09

2.42E-07

Positive regulation of interleukin-10 production

IL13, IL6, CD40LG, IL4,

3.75E-08

5.62E-06

T-helper cell differentiation

GATA3, IL6, TBX21, IL4

5.39E-08

7.68E-06

Macrophage activation

IL13, IFNG, IL4, TNF

9.23E-08

1.19E-05

Positive regulation of interleukin-13 production

GATA3, IL4

1.67E-07

1.96E-05

Vascular endothelial growth factor production

TNF, IL6, IFN

2.22E-07

2.46E-05

Microglial cell activation

IFNG, IL4, TNF

5.63E-07

5.55E-05

Positive regulation of cytokine production involved in inflammatory response

IL6, TNF, IL17A

2.30E-06

1.80E-04

Regulation of acute inflammatory response

IL6, IL4, TNF

2.92E-06

2.19E-04

Regulation of complement-dependent cytotoxicity

IL13, IL4

6.31E-06

4.07E-04

Wnt signaling pathway involved in kidney development

GATA3

1.05E-05

6.22E-04

Positive regulation of vitamin metabolic process

IFNG, TNF

1.05E-05

6.36E-04

Detection of lipopolysaccharide

LY96

2.94E-05

1.50E-03

Positive regulation of mast cell activation involved in immune response

IFNG, TNF

6.91E-05

2.96E-03

Positive regulation of interleukin-23 production

GATA3

3.78E-05

1.82E-03

Positive regulation of interleukin-5 production

GATA3

3.78E-05

1.82E-03

Positive regulation of isotype switching to IgG isotypes

TBX21, IL4

4.72E-05

2.17E-03

GO molecular function

Tumor necrosis factor receptor binding

TNF, CD40LG,

3.51E-10

1.97E-07

CD40 receptor binding

CD40LG

3.54E-08

1.59E-05

CXCR chemokine receptor binding

CXCL8, CXCL10

9.73E-07

3.65E-04

Interleukin-8 receptor binding

CXCL8,

6.31E-06

2.18E-03

Toll-like receptor 4 binding

LY96

1.58E-05

4.73E-03

Interleukin-2 receptor binding

GATA3, IL2

2.20E-05

5.83E-03

Lipopolysaccharide immune receptor activity

LY96

2.94E-05

7.34E-03

Toll-like receptor binding

LY96

9.51E-05

2.14E-02

GO cellular component

Lipopolysaccharide receptor complex

LY96

3.78E-05

1.77E-02