Fig. 3

Illustration of the distribution of LOY in different types of CD4 + T lymphocytes, as well as their developmental trajectories. The full UMAP can be seen in Supplementary Fig. 10B. (A) The distribution of the identified cell types. (B) The LOY status of the cells in A, with LOY-cells being marked red. (C) Developmental trajectory of CD4 + T lymphocytes. Colour denotes pseudotime, with more developed cells being brighter. The lines indicate the suggested trajectories from naive to more differentiated CD4 + cells.