Fig. 3

Single-cell transcription analysis and regulatory network centered on FLI1 in BRCA. A UMAP visualization of 99,532 cells analyzed by scRNA-seq and integrated across thirteen normal breast tissues, seven pairs of breast tumors, and corresponding lymph node samples, categorized into six major cell types. B UMAP visualization of all cells split by sample group. C The dot plot shows the expression of FLI1 in each cell type split by sample group. D UMAP visualization of the activity of FLI1 regulons in each cell type. E The heatmap shows the activities of the regulons of FLI1 and other cofactors in each cell type split by sample group. Colors from blue to red indicate low to high regulon activity (F). The ratio of each cell type in the normal and tumor groups. G Ridgeline plots and violin plots show the AUC values of the FLI1 regulatory network in each normal and tumor group cell type. N, normal. T, tumor. L, lymph node