Fig. 4

Global intercellular communication in BRCA. A Circle plots show the interaction numbers among all six cell types across different groups. B Bar plots show the total interaction number and interaction strength in different groups. C Scatter plots show the interaction strength of the incoming and outgoing of each cell type across different groups. D Heatmaps summarize the overall signal pathways of each cell group among all samples. E Differential number or strength of interactions in the tumor and normal groups. The red and blue lines indicate a signal increase and decrease in the tumor compared to the normal group. F Heatmaps show the differential number or strength of tumor interactions compared with the normal group. G The specific interaction numbers among myeloid cells, T cells, and endothelial cells in normal and tumor groups. N, normal. T, tumor. L, lymph node