Fig. 8

A model of transcriptional regulation in bovine satellite cells. In proliferating bovine satellite cells, genes that regulate cell cycle (e.g., CCND1) and genes that inhibit myoblast differentiation (e.g., ID1) are activated by the AP-1 family transcription factors and the myogenic regulatory factor 5 (MYF5) binding to active enhancers marked with H3K4me1 and H3K27ac, whereas genes that stimulate myoblast differentiation (e.g., MYOG) and fusion (e.g., MYMK) are repressed by the PRC-2 complex potentially recruited to repressed enhancers by the transcription factors NF-kB and ZEB-1. In differentiating bovine satellite cells, genes that encode proteins important for muscle contraction (e.g., MYH3) and for myoblast fusion (e.g., MYMK) are activated by the transcription factors MYOG and TFAP4 binding to active enhancers whereas genes that stimulate cell proliferation (e.g., CCND1) and inhibit myoblast differentiation (e.g., ID2) are repressed by the PRC-2 complex