Fig. 1
From: DPPA3 facilitates genome-wide DNA demethylation in mouse primordial germ cells
CG methylation reprogramming is partially impaired in Dppa3KO PGCs. (A) Chronology of PGC development and oocyte growth and changes in 5mC and 5hmC levels and Dppa3 and Uhrf1 expression. NGO, non-growing oocyte; GO, growing oocyte; FGO, fully grown oocyte. (B) Violin plots showing the distributions of regional CG methylation levels (in 10-kb windows) in control and KO PGCs and FGOs (only windows informative in all samples were used, n = 249,088). Published WGBS data [6, 11] were retrieved and reprocessed for wild-type epiblasts, E9.5 PGCs, and E10.5 PGCs. Horizontal bars indicate the median values. The global CG methylation levels are indicated above the plots. (C) CG methylation profiles of a portion of mouse chromosome 1. RefSeq genes are indicated at the bottom. (D) Scatterplots comparing regional CG methylation levels (10-kb windows, n = 249,088) in control and KO PGCs and FGOs