Fig. 1

Induction of OmoMYC causes widespread gene expression changes. (a) Volcano plot showing data for all genes analyzed following induction of OmoMYC versus EGFP in engineered CHP-134 cells for three days. Blue dots indicate genes decreased in expression by a fold change of < -1.5 and FDR < 0.05. Red dots indicate genes that increased in expression by a fold change of > 1.5 and FDR < 0.05. (b) Gene set enrichment analysis was performed to compare OmoMYC-induced changes in gene expression against the MSigDB Hallmark data sets. Genes that increased in expression are significantly enriched among the gene categories shown. (c) Gene set enrichment analysis was performed to compare OmoMYC-induced changes in gene expression against the MSigDB Hallmark data sets. Genes that decreased in expression are significantly enriched among the gene categories shown. Additional gene categories are noted in Additional File 2: Table S2