Fig. 3From: Common occurrence of hotspots of single strand DNA breaks at transcriptional start sitesSSB hotspots are enriched on the template strand in the immediate vicinity of TSSs. (A) Aggregate plots of the normalized density scores (Y-axes) of the positions of all SSBs or sample-shared hotspots (depth ≥ 1) within ± 200 bp of the TSSs for heart (A). The signal from the template and nontemplate strands is shown respectively above and below the zero lines. (B, C) Odds ratios (Y-axes) of enrichment of sample-shared SSB hotspots (depth ≥ 1) found on other template or non-template strands in the indicated non-overlapping distance bins to TSSs in the different tissues (X-axes). Due to the differences in the magnitudes of the odds ratios, the Y-axes in (B) and (C) have different scales. (D) The template vs. nontemplate ratios (Y-axes) of SSB hotspots in each distance and each tissue. (B–D) The red dashed horizontal lines represent odds ratios (B, C) or template vs. nontemplate ratio of 1 that represent respectably no enrichment or no strand preference. See Supplementary Table 3 for the exact numbers and Methods for more detailsBack to article page