Fig. 6

SSB hotspots have a tendency to be found downstream of cytosines leading to cytosine enrichment of regions around TSSs associated with the hotspots. The top 3 sequence motifs represent motifs around all SSB hotspots found genome-wide and only those found on either template or non-template strands in ± 5 bp vicinity around TSSs. The bases immediately upstream of the breaks are highlighted. The bottom two motifs represent the difference in the sequence compositions around TSSs that contain SSB hotspots on either template or non-template strand vs. the sequences around all TSSs. Only bases with differences > 0.05 (5%, Y-axes) at each position are shown. Positive values on Y-axes indicate enrichment in the TSSs with the SSB hotspots. The TSSs are highlighted. See Supplemental Tables 7 and Methods for more details