Fig. 2

Auditory phenotype of P30 Dfnb1^em274 HOM mice. a ABR in response to click stimulus at different level from 90 to 30 dB SPL, in WT, HET and HOM Dfnb1^em274 mice. Latin numbers (I-V) indicate the standard ABR peaks. b Scheme showing the main neural centers in the auditory pathway and their correspondence with the ABR wave peaks (AN (I): auditory nerve; CN (II), cochlear nucleus; SOC (III): superior olivary complex; LL (IV): lateral lemniscus; IC (V), inferior colliculus; NLL: Lateral lemniscus nuclei; MGB, medial geniculate body; SC, superior colliculus; TL, temporal lobe; AC, auditory cortex. c, d ABR thresholds (in dB SPL) in response to click (c) and 4–40 kHz pure tones (d) in WT (white), HET (grey) and HOM (black) Dfnb1^em274 mice. Statistically significant differences in click and 4, 8 and 16 kHz thresholds were found between WT and HOM mutant mice. (e) Input–output curves (latency/intensity and amplitude/intensity) for ABR peak I and (f) wave interpeak latencies I-II, II-IV and I-IV in WT and HET mutant mice