Fig. 2

Features of Portuguese BRCA variation. A Clinical classification of BRCA variants. P: Pathogenic; PLP: Pathogenic or Likely Pathogenic; LP: Likely Pathogenic; B: Benign; LB: Likely Benign; BLB: Benign or Likely Benign; VUS: Variants of Uncertain Significance; CIP: Conflicted Interpretation of Pathogenicity; U: Unknown. B BRCA PVs identified in Portuguese cancer cohort. The left pie showed 4.8% of 11,482 Portuguese cancer patients were the BRCA PV carriers; the right pie showed that 59.5% of the PV carriers carried the three Portuguese founder pathogenic variants, and 40.5% carried non-founder pathogenic variants. C Large structural variants in Portuguese BRCA variation