Volume 15 Supplement 6
Proceedings of the Twelfth Annual Research in Computational Molecular Biology (RECOMB) Satellite Workshop on Comparative Genomics
Proceedings
Edited by Laxmi Parida, Gurinder Atwal and Bud Mishra
Publication of this supplement has not been supported by sponsorship. Information about the source of funding for publication charges can be found in the individual articles. The peer review process was overseen by the Supplement Editors in accordance with BioMed Central's peer review guidelines for supplements. The Supplement Editors declare that they have no competing interests.
Twelfth Annual Research in Computational Molecular Biology (RECOMB) Satellite Workshop on Comparative Genomics. Go to conference site.
Cold Spring Harbor, NY, USA19-22 October 2014
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Citation: BMC Genomics 2014 15(Suppl 6):I1
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Near-medians that avoid the corners; a combinatorial probability approach
The breakpoint median for a set of k ≥ 3 random genomes tends to approach (any) one of these genomes ("corners") as genome length increases, although there are diminishing proportion of medians equidistant from a...
Citation: BMC Genomics 2014 15(Suppl 6):S1 -
Identifying gene clusters by discovering common intervals in indeterminate strings
Comparative analyses of chromosomal gene orders are successfully used to predict gene clusters in bacterial and fungal genomes. Present models for detecting sets of co-localized genes in chromosomal sequences ...
Citation: BMC Genomics 2014 15(Suppl 6):S2 -
Sets of medians in the non-geodesic pseudometric space of unsigned genomes with breakpoints
The breakpoint median in the set S n of permutations on n terms is known to have some unusual behavior, especially if the input genomes are maximally different to each other...
Citation: BMC Genomics 2014 15(Suppl 6):S3 -
Open adjacencies and k-breaks: detecting simultaneous rearrangements in cancer genomes
The evolution of a cancer genome has traditionally been described as a sequential accumulation of mutations - including chromosomal rearrangements - over a period of time. Recent research suggests, however, th...
Citation: BMC Genomics 2014 15(Suppl 6):S4 -
Gene order alignment on trees with multiOrthoAlign
We relate the comparison of gene orders to an alignment problem. Our evolutionary model accounts for both rearrangement and content-modifying events. We present a heuristic based on dynamic programming for the...
Citation: BMC Genomics 2014 15(Suppl 6):S5 -
What is the difference between the breakpoint graph and the de Bruijn graph?
The breakpoint graph and the de Bruijn graph are two key data structures in the studies of genome rearrangements and genome assembly. However, the classical breakpoint graphs are defined on two genomes (repres...
Citation: BMC Genomics 2014 15(Suppl 6):S6 -
Disk covering methods improve phylogenomic analyses
With the rapid growth rate of newly sequenced genomes, species tree inference from multiple genes has become a basic bioinformatics task in comparative and evolutionary biology. However, accurate species tree ...
Citation: BMC Genomics 2014 15(Suppl 6):S7 -
Gene families as soft cliques with backbones: Amborellacontrasted with other flowering plants
Chaining is a major problem in constructing gene families.
Citation: BMC Genomics 2014 15(Suppl 6):S8 -
Robustness of birth-death and gain models for inferring evolutionary events
Phylogenetic birth-death models are opening a new window on the processes of genome evolution in studies of the evolution of gene and protein families, protein-protein interaction networks, microRNAs, and copy...
Citation: BMC Genomics 2014 15(Suppl 6):S9 -
Explaining evolution via constrained persistent perfect phylogeny
The perfect phylogeny is an often used model in phylogenetics since it provides an efficient basic procedure for representing the evolution of genomic binary characters in several frameworks, such as for examp...
Citation: BMC Genomics 2014 15(Suppl 6):S10 -
BBCA: Improving the scalability of *BEAST using random binning
Species tree estimation can be challenging in the presence of gene tree conflict due to incomplete lineage sorting (ILS), which can occur when the time between speciation events is short relative to the popula...
Citation: BMC Genomics 2014 15(Suppl 6):S11 -
Orthology and paralogy constraints: satisfiability and consistency
A variety of methods based on sequence similarity, reconciliation, synteny or functional characteristics, can be used to infer orthology and paralogy relations between genes of a given gene family
Citation: BMC Genomics 2014 15(Suppl 6):S12 -
Properties and determinants of codon decoding time distributions
Codon decoding time is a fundamental property of mRNA translation believed to affect the abundance, function, and properties of proteins. Recently, a novel experimental technology--ribosome profiling--was deve...
Citation: BMC Genomics 2014 15(Suppl 6):S13 -
Estimation of prokaryotic supergenome size and composition from gene frequency distributions
Because prokaryotic genomes experience a rapid flux of genes, selection may act at a higher level than an individual genome. We explore a quantitative model of the distributed genome whereby groups of genomes ...
Citation: BMC Genomics 2014 15(Suppl 6):S14 -
Recombination-aware alignment of diploid individuals
Traditionally biological similarity search has been studied under the abstraction of a single string to represent each genome. The more realistic representation of diploid genomes, with two strings defining th...
Citation: BMC Genomics 2014 15(Suppl 6):S15 -
A meta-approach for improving the prediction and the functional annotation of ortholog groups
In comparative genomics, orthologs are used to transfer annotation from genes already characterized to newly sequenced genomes. Many methods have been developed for finding orthologs in sets of genomes. Howeve...
Citation: BMC Genomics 2014 15(Suppl 6):S16 -
Viral diversity and clonal evolution from unphased genomic data
Clonal expansion is a process in which a single organism reproduces asexually, giving rise to a diversifying population. It is pervasive in nature, from within-host pathogen evolution to emergent infectious di...
Citation: BMC Genomics 2014 15(Suppl 6):S17 -
Comparative exomics of Phalariscultivars under salt stress
Reed canary grass (Phalaris arundinacea) is an economically important forage and bioenergy grass of the temperate regions of the world. Despite its economic importance, it is lacking in public genomic data. We ex...
Citation: BMC Genomics 2014 15(Suppl 6):S18 -
Gene expression and fractionation resistance
Previous work on whole genome doubling in plants established the importance of gene functional category in provoking or suppressing duplicate gene loss, or fractionation. Other studies, particularly in Paramecium
Citation: BMC Genomics 2014 15(Suppl 6):S19 -
Estimating the information value of polymorphic sites using pooled sequences
High-throughput sequencing is a cost effective method for identifying genetic variation, and it is currently in use on a large scale across the field of biology, including ecology and population genetics. Corr...
Citation: BMC Genomics 2014 15(Suppl 6):S20
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