Major functional changes in very early HCCs. The top ranked GSs (the dash box in Figure 5D) are organized into an acyclic network according to their GO term relationships. Each node represents one GS, and node color represents its ranking order by eGSA (up-REs in red while down-ones green). The GO term of a GS is labeled on the node. Several linking nodes (white) are added to cluster nodes into function-related branches.