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Table 2 Most common Gene Ontology functional categories †

From: Genomic evidence for non-random endemic populations of decaying exons from mammalian genes

Homo sapiens
All genes (Total = 31524) ΨEs (Total = 284) DEs (Total = 1341)
GO:0005515, protein binding (5864) GO:0043167, ion binding (92)*§ GO:0005515, protein binding (372)
GO:0043167, ion binding (3861) GO:0003676, nucleic acid binding (74)*§ GO:0043167, ion binding (349)*
GO:0003676, nucleic acid binding (3251) GO:0005515, protein binding (34) GO:0003676, nucleic acid binding (176)
GO:0016787, hydrolase activity (2053) GO:0016740, transferase activity (18) GO:0016787, hydrolase activity (105)
GO:0000166, nucleotide binding (1992) GO:0004872, receptor activity (13) GO:0004872, receptor activity (84)
GO:0004872, receptor activity (1765) GO:0000166, nucleotide binding (12) GO:0000166, nucleotide binding (57)
GO:0016740, transferase activity (1631) GO:0016491, oxidoreductase activity (11)§ GO:0016740, transferase activity (36)
GO:0016491, oxidoreductase activity (723) GO:0016787, hydrolase activity (10) GO:0030246, carbohydrate binding (35)*
GO:0015075, ion transporter activity (541) GO:0030246, carbohydrate binding (6) GO:0005201, extracellular matrix structural constituent (22)*
GO:0008289, lipid binding (420) GO:0046906, tetrapyrrole binding (3) GO:0004857, enzyme inhibitor activity (21)
Mus musculus
All genes (Total = 28390) ΨEs (Total = 209) DEs (Total = 1079)
GO:0005515, protein binding (5553) GO:0043167, ion binding (55)* GO:0005515, protein binding (374)*
GO:0043167, ion binding (3672) GO:0003676, nucleic acid binding (43)* GO:0043167, ion binding (321)*
GO:0003676, nucleic acid binding (3382) GO:0004872, receptor activity (27)§ GO:0003676, nucleic acid binding (173)
GO:0004872, receptor activity (2779) GO:0016787, hydrolase activity (16) GO:0016787, hydrolase activity (114)
GO:0016787, hydrolase activity (2260) GO:0005515, protein binding (14) GO:0004872, extracellular matrix (109)
GO:0000166, nucleotide binding (2061) GO:0016491, oxidoreductase activity (9) GO:0000166, nucleotide binding receptor activity (91)
GO:0016740, transferase activity (1805) GO:0004857, enzyme inhibitor activity (7)  
GO:0016491, oxidoreductase activity (911) GO:0000166, nucleotide binding (7) GO:0016740, transferase activity (51)
GO:0015075, ion transporter activity (598) GO:0046906, tetrapyrrole binding (6) GO:0030246, carbohydrate binding (41)*
GO:0008289, lipid binding (401) GO:0016740, transferase activity (5) GO:0005201, structural constituent (40)*
   GO:0016491, oxidoreductase activity (25)
Rattus norvegicus
All genes (Total = 27302) ΨEs (Total = 218) DEs (Total = 993)
GO:0005515, protein binding (2732) GO:0043167, ion binding (23) GO:0043167, ion binding (158)*
GO:0043167, ion binding (2238) GO:0016740, transferase activity (16)§ GO:0005515, protein binding (155)*
GO:0004872, receptor activity (2063) GO:0003676, nucleic acid binding (15) GO:0003676, nucleic acid binding (74)
GO:0003676, nucleic acid binding (1720) GO:0004872, receptor activity (14) GO:0016787, hydrolase activity (62)
GO:0000166, nucleotide binding (1406) GO:0005515, protein binding (12) GO:0000166, nucleotide binding (46)
GO:0016787, hydrolase activity (1331) GO:0016787, hydrolase activity (12) GO:0004872, receptor activity (37)
GO:0016740, transferase activity (1179) GO:0000166, nucleotide binding (10) GO:0016740, transferase activity (29)
GO:0016491, oxidoreductase activity (594) GO:0016491, oxidoreductase activity (6) GO:0016491, oxidoreductase activity (16)
GO:0015075, ion transporter activity (392) GO:0046906, tetrapyrrole binding (5) GO:0030246, carbohydrate binding (16)
GO:0003735, structural constituent of ribosome (284) GO:0030246, carbohydrate binding (4) GO:0005201, extracellular matrix structural constituent (14)*
  1. * Over-represented term when compared with all genes.
  2. § Over-represented term when compared with DEs.
  3. † GO term counts are listed for human, mouse and rat.