Breakpoint density and small intergene coverage decrease with distance to putative replication origins. (a) (open triangle, point up) Intergenic breakpoint density estimated using model M1 of the BPR data set versus the genomic distance to the closest putative origin located in the replication N-domains. (small open triangle, point down) Estimated intergenic breakpoint density in 100 kb windows along replication N-domains versus the distance to the closest ORI assuming that breakpoint density solely depends on the intergene size according to the fit of the breakpoint density versus intergenic size presented in Figure 2. Bars as in Figure 2. (b) Coverage of small intergenes (L ≤ 150 kb) in 50 kb windows along replication N-domains versus the genomic distance to the closest putative replication origin. Small intergene coverage corresponds to the proportion of the sequence covered by a small intergene within the window of interest.