Figure 5

Open chromatin regions present a high breakpoint density. Intergenic breakpoint density estimated using model M1 versus (a) CpG ratio and (b) coverage by DNase I hypersensitive sites. Data points were obtained by (i) ordering 50 kb windows according to their CpG ratio (resp. Dnase I HS sites coverage), (ii) grouping them into classes of equal number of intergenic breakpoints and (iii) computing intergenic breakpoint density and average CpG ratio (resp. Dnase I HS sites coverage) over each class. Vertical bars represent the standard deviations (see Methods); horizontal bars represent the ranges of CpG ratio (resp. Dnase I HS sites coverage) over each class.