Table 6 Metacore analysis of the pathways modified by 1,25(OH)2D treatment in RWPE1 cells (p < 0.05).
Metacore Map | p-Value | Genes changed |
|---|---|---|
6 h induced: 83 maps at p < 0.05 | ||
Apoptosis and survival_NGF activation of NF-kB | 2.89E-03 | 6 |
Transcription: p53 signaling pathway | 2.33E-02 | 5 |
Inhibitory action of Lipoxins on pro-inflammatory TNF-alpha signaling | 2.33E-02 | 5 |
Arachidonic acid production | 1.76E-03 | 6 |
6 h suppressed: 28 maps at p < 0.05 | ||
Transcription_NF-kB signaling pathway | 2.29E-02 | 4 |
Development_WNT signaling pathway. Part 2 | 1.48E-02 | 6 |
Development_Notch signaling pathway | 4.17E-02 | 4 |
Transcription_Androgen receptor nuclear signaling | 3.68E-02 | 5 |
24 h induced: 30 maps at p < 0.05 | ||
Oxidative phosphorylation | 5.66E-04 | 13 |
Cell adhesion_ECM remodeling | 2.02E-02 | 7 |
Role of tetraspanins in the integrin-mediated cell adhesion | 4.62E-02 | 6 |
Prostaglandin 2 biosynthesis and metabolism FM | 2.93E-03 | 5 |
24 h suppressed: 84 maps at p < 0.05 | ||
Immune response_IL6 signaling pathway | 3.85E-03 | 10 |
Immune response_IFN gamma signaling pathway | 2.06E-04 | 9 |
Cell cycle Nucleocytoplasmic transport of CDK/Cyclins | 6.04E-05 | 7 |
Cell cycle_Role of APC in cell cycle regulation | 7.19E-03 | 6 |
48 h induced: 53 maps at p < 0.05 | ||
Cell cycle_Regulation of G1/S transition (part 2) | 6.07E-03 | 6 |
Oxidative phosphorylation | 2.17E-02 | 11 |
Regulation of lipid metabolism_Insulin regulation of fatty acid metabolism | 1.37E-02 | 8 |
Glycolysis and gluconeogenesis (short map) | 3.43E-03 | 7 |
Apoptosis and survival_p53-dependent apoptosis | 3.54E-02 | 5 |
Prostaglandin 2 biosynthesis and metabolism FM | 1.27E-03 | 6 |
48 h suppressed: 140 maps at p < 0.05 | ||
Cell cycle_Role of APC in cell cycle regulation | 2.92E-04 | 14 |
Immune response_Antiviral actions of Interferons | 4.07E-05 | 16 |
Immune response_PGE2 common pathways | 5.22E-04 | 16 |
Development_TGF-beta receptor signaling | 3.94E-04 | 15 |
Development_VEGF-family signaling | 1.68E-02 | 9 |
Peroxisomal branched chain fatty acid oxidation | 3.51E-04 | 8 |
All times induced: 66 maps at p < 0.05 | ||
Cytoskeleton remodeling_Keratin filaments | 8.37E-04 | 13 |
Development_TGF-beta receptor signaling | 8.65E-03 | 13 |
Development_VEGF signaling and activation | 3.92E-02 | 10 |
Cell Adhesion_ECM remodeling | 3.94E-02 | 11 |
Apoptosis and survival_caspase cascade | 6.47E-03 | 9 |
All times suppressed: 155 maps at p < 0.05 | ||
Immune Response_IL-27 signaling pathway | 3.14E-04 | 12 |
Development_Notch Signaling Pathway | 5.70E-04 | 16 |
Cell cycle_Regulation of G1/S transition (part 1) | 6.25E-07 | 24 |
Transcription_Androgen Receptor nuclear signaling | 3.38E-03 | 18 |
Cell adhesion_Ephrins signaling | 8.47E-03 | 14 |
Development_VEGF-family signaling | 3.86E-02 | 10 |